2-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridine

2-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridine, identified by CAS 2223041-77-6, is a highly functionalized pyridine compound. It incorporates a fluorine atom, a trifluoromethyl group, and a pinacol boronate ester moiety. The pinacol boronate group serves as a robust and versatile handle for various cross-coupling reactions, especially the Suzuki-Miyaura coupling, enabling the formation of new carbon-carbon bonds with aryl or heteroaryl halides. The presence of fluorine and trifluoromethyl groups often imparts unique physicochemical properties, such as increased lipophilicity, metabolic stability, and altered electronic profiles, making this compound particularly relevant for the synthesis of novel fluorinated pharmaceuticals, agrochemicals, and materials in research settings. Its structure positions it as a key intermediate in the development of complex organic molecules for research use.

• For research use only. Handle 2-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridine in a well-ventilated area or fume hood. Wear appropriate personal protective equipment, including safety goggles, gloves, and a lab coat, to prevent skin and eye contact. Avoid inhalation of dust or vapors. In case of contact, rinse immediately with plenty of water. Consult the Safety Data Sheet (SDS) for detailed hazard information and safe handling procedures. Store in a cool, dry place, away from incompatible materials.