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2-Fluoro-6-(trifluoromethyl)pyridine-4-boronic acid pinacol ester

CAS 1169459-44-2Formula C12H14BF4NO2MW 291.05PubChem 53417043

This compound is a fluorinated pyridine derivative featuring a trifluoromethyl group and a pinacol boronic ester. It serves as a versatile building block in organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions.

Loading RDKit molecule structure...
InChIKey: KHMFQIHEKLSQCH-UHFFFAOYSA-NC12H14BF4NO2 | MW 291.05

Chemical Identity

Molecular Formula

C12H14BF4NO2

Molecular Weight

291.05 g/mol

Exact Mass

291.105372

PubChem CID

53417043

IUPAC Name

2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine

SMILES String

CC1(C)OB(c2cc(F)nc(C(F)(F)F)c2)OC1(C)C

Names & Synonyms

870-759-82-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)-PyridineZ20497548572-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine
External Identifiers
RefChem:472524MFCD12923444starbld0018985SCHEMBL1674073UWB45944CS-29447DB-293027EN300-23703812

Catalog Overview

2-Fluoro-6-(trifluoromethyl)pyridine-4-boronic acid pinacol ester is a highly functionalized pyridine derivative. It incorporates a fluorine atom and a trifluoromethyl group on the pyridine ring, along with a pinacol boronic ester moiety at the 4-position. This combination of functional groups makes it a valuable intermediate in the synthesis of complex organic molecules, especially in medicinal chemistry and materials science. The boronic ester group allows for facile C-C bond formation through Suzuki-Miyaura coupling, while the fluorine and trifluoromethyl groups can impart specific electronic and steric properties to the final...

Use Context

  • Research chemical sourcing
  • Custom synthesis and catalog availability review
  • COA, SDS, pricing, and fulfillment workflow
Read more catalog context

2-Fluoro-6-(trifluoromethyl)pyridine-4-boronic acid pinacol ester is a highly functionalized pyridine derivative. It incorporates a fluorine atom and a trifluoromethyl group on the pyridine ring, along with a pinacol boronic ester moiety at the 4-position. This combination of functional groups makes it a valuable intermediate in the synthesis of complex organic molecules, especially in medicinal chemistry and materials science. The boronic ester group allows for facile C-C bond formation through Suzuki-Miyaura coupling, while the fluorine and trifluoromethyl groups can impart specific electronic and steric properties to the final compounds.

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

white crystalline solid

Physical State

solid

Melting Point

97.0 °C

Boiling Point

242.0 °C

Density

1.5 g/cm³

Water Solubility

5.89 × 10⁻⁴ mol/L

Flash Point

120.0 °C

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • Handle with appropriate personal protective equipment, including gloves, eye protection, and a lab coat. Use in a well-ventilated area or under a fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Refer to the Safety Data Sheet (SDS) for comprehensive safety information. This product is for research use only and not for human or animal therapeutic or diagnostic use.

Related Products / Graph Discovery

Related products, derivatives, keywords, and application cues for catalog discovery.

Similar products (text references)

2710289-79-3CAS 2710289-79-3

Recommended application cues

Research intermediateCustom synthesis building block

Catalog discovery cues, not supplier-verified claims.

Related HS Code / Compliance

HS Code: 293339GHS Pictograms: GHS07Shipment review: Shipment details require review before fulfillment.

Compliance cues are non-linked reference tags and require shipment review.

Catalog navigation

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.