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Home/Compounds/CAS 120685-11-2
Formula C35H30N4O4MW 570.6Research-use catalog entryCOA/SDS by request

Midostaurin

CAS Number: 120685-11-2

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Loading RDKit molecule structure...
InChIKey: BMGQWWVMWDBQGC-IIFHNQTCSA-NC35H30N4O4 | MW 570.6

Chemical Absolute Identifiers

CAS Number

120685-11-2

PubChem CID

9829523

Molecular Formula

C35H30N4O4

Molecular Weight

570.6 g/mol

Exact Mass

570.226705

InChIKey

BMGQWWVMWDBQGC-IIFHNQTCSA-N

IUPAC Name

N-[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methylbenzamide

SMILES String

CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4

Physical Properties

Water Solubility

1 mol/L

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Midostaurin (CAS 120685-11-2) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C35H30N4O4 and molecular weight 570. 60 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens) — 39 assays; Mast/stem cell growth factor receptor Kit (Homo sapiens) — 25 assays; Epidermal growth factor receptor (Homo sapiens) — 32 assays; Serine/threonine-protein kinase TBK1 (Homo sapiens) — 5 assays; Serine/threonine-protein kinase N1 (Homo sapiens) — 4 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Receptor-type tyrosine-protein kinase FLT3

Homo sapiens · SINGLE PROTEIN · 39 qualifying assays · 16 documents · best pChEMBL 9

Experimental evidence source: ChEMBL

Mast/stem cell growth factor receptor Kit

Homo sapiens · SINGLE PROTEIN · 25 qualifying assays · 7 documents · best pChEMBL 8.11

Experimental evidence source: ChEMBL

Epidermal growth factor receptor

Homo sapiens · SINGLE PROTEIN · 32 qualifying assays · 6 documents · best pChEMBL 8.06

Experimental evidence source: ChEMBL

Serine/threonine-protein kinase TBK1

Homo sapiens · SINGLE PROTEIN · 5 qualifying assays · 4 documents · best pChEMBL 8.03

Experimental evidence source: ChEMBL

Serine/threonine-protein kinase N1

Homo sapiens · SINGLE PROTEIN · 4 qualifying assays · 4 documents · best pChEMBL 8.03

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Midostaurin

Names & Synonyms

Cgp 41251PKC 412RYDAPTN-BenzoylstaurosporineBenzoylstaurosporine
Show all synonyms
midostaurinamidostaurineCgp 41 251N-((9S,10R,11R,13R)-10-methoxy-9-methyl-1-oxo-2,3,10,11,12,13-hexahydro-9,13-epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-11-yl)-N-methylbenzamideBenzamide, N-(2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-1-oxo-8,12-epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-10-yl)-N-methyl-, (8alpha,9beta,10beta,12alpha)-N-benzoyl-staurosporineBenzamide, N-((9S,10R,11R,13R)-2,3,9,10,11,12-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-11-yl)-N-methyl-midostaurinum4'-N-benzoyl staurosporine4'-N-BenzoylstaurosporineMidostaurin [INN]Midostaurin [USAN:INN]Rydapt (TN)MIDOSTAURIN [MI]MIDOSTAURIN [JAN]
External Identifiers
EC NUMBER: 848-383-0DSSTOX SUBSTANCE ID: DTXSID201372777CHEMBL ID: CHEMBL608533CHEBI ID: CHEBI:63452UNII: ID912S5VONDRUGBANK ID: DB06595KEGG ID: D05029METABOLOMICS WORKBENCH ID: 62790NCI THESAURUS CODE: C1872PHARMGKB ID: PA166169917RXCUI: 1919083WIKIDATA ID: Q6842945
Literature & Patent References
DOI 10.1016/j.ejmech.2024.117166Discovery of the first examples of right open reading frame kinase 2 (RIOK2) molecular glue degraders.DOI 10.1021/acs.jmedchem.4c03084Design, Synthesis, and Biological Evaluation of Novel Fms-Like Tyrosine Kinase 3/VEGFR2/Histone Deacetylase Inhibitors for the Treatment of Acute Myeloid Leukemia.PMID 39721086Discovery of the first examples of right open reading frame kinase 2 (RIOK2) molecular glue degraders.PMID 39970471Design, Synthesis, and Biological Evaluation of Novel Fms-Like Tyrosine Kinase 3/VEGFR2/Histone Deacetylase Inhibitors for the Treatment of Acute Myeloid Leukemia.DOI 10.1016/j.ejmech.2024.116540Non-kinase off-target inhibitory activities of clinically-relevant kinase inhibitors.DOI 10.1016/j.ejmech.2024.116717FLT3-PROTACs for combating AML resistance: Analytical overview on chimeric agents developed, challenges, and future perspectives.DOI 10.1021/acs.jmedchem.4c00051Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors.DOI 10.1039/d3md00677hIndole-containing pharmaceuticals: targets, pharmacological activities, and SAR studies.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

StaurosporineCAS 62996-74-1
N-methylbenzohydrazideCAS 1483-24-5

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 571190-30-2PalbociclibCAS 62996-74-1StaurosporineCAS 443913-73-3VandetanibCAS 670220-88-9CrenolanibCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acidCAS 1018144-00-72-(3-Cyclopropyl-6-isopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 120685-11-2

What are the key identifiers for Midostaurin (CAS 120685-11-2)?

Midostaurin is identified by CAS 120685-11-2, with molecular formula C35H30N4O4, molecular weight 570.6, InChIKey BMGQWWVMWDBQGC-IIFHNQTCSA-N.

Does CAS 120685-11-2 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Receptor-type tyrosine-protein kinase FLT3, Mast/stem cell growth factor receptor Kit, Epidermal growth factor receptor, Serine/threonine-protein kinase TBK1, Serine/threonine-protein kinase N1. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 120685-11-2?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Midostaurin?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 120685-11-2 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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