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CAS Number: 163451-81-8
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CAS Number
163451-81-8
PubChem CID
54684141
Molecular Formula
C12H9F3N2O2
Molecular Weight
270.21 g/mol
Exact Mass
270.061612
InChIKey
UTNUDOFZCWSZMS-YFHOEESVSA-N
IUPAC Name
(Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide
SMILES String
C/C(O)=C(\C#N)C(=O)Nc1ccc(C(F)(F)F)cc1
No physical property values available.
Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.
Structural features
Teriflunomide (CAS 163451-81-8) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C12H9F3N2O2 and molecular weight 270. 21 g/mol.
Sourcing context
Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.
Research use context
Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.
Documentation needs
COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.
ChEMBL reports experimental activity evidence for: Dihydroorotate dehydrogenase (quinone), mitochondrial (Rattus norvegicus) — 7 assays; Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens) — 27 assays; Dihydroorotate dehydrogenase (quinone), mitochondrial (Mus musculus) — 4 assays; Dihydroorotate dehydrogenase (Plasmodium falciparum) — 4 assays; Alpha-1A adrenergic receptor (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.
Dihydroorotate dehydrogenase (quinone), mitochondrial
Rattus norvegicus · SINGLE PROTEIN · 7 qualifying assays · 7 documents · best pChEMBL 8.05
Experimental evidence source: ChEMBL
Dihydroorotate dehydrogenase (quinone), mitochondrial
Homo sapiens · SINGLE PROTEIN · 27 qualifying assays · 21 documents · best pChEMBL 7.52
Experimental evidence source: ChEMBL
Dihydroorotate dehydrogenase (quinone), mitochondrial
Mus musculus · SINGLE PROTEIN · 4 qualifying assays · 4 documents · best pChEMBL 7.16
Experimental evidence source: ChEMBL
Dihydroorotate dehydrogenase
Plasmodium falciparum · SINGLE PROTEIN · 4 qualifying assays · 4 documents · best pChEMBL 5.41
Experimental evidence source: ChEMBL
Alpha-1A adrenergic receptor
Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 4.68
Experimental evidence source: ChEMBL
Safety and handling reference content is available through documentation requests.
For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.
Preliminary Safety Reference
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Safety Reference / SDS RequestCatalog navigation
Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.
Teriflunomide is identified by CAS 163451-81-8, with molecular formula C12H9F3N2O2, molecular weight 270.21, InChIKey UTNUDOFZCWSZMS-YFHOEESVSA-N.
ChEMBL contains qualifying experimental assay evidence associated with Dihydroorotate dehydrogenase (quinone), mitochondrial, Dihydroorotate dehydrogenase (quinone), mitochondrial, Dihydroorotate dehydrogenase (quinone), mitochondrial, Dihydroorotate dehydrogenase, Alpha-1A adrenergic receptor. These records do not establish therapeutic efficacy or clinical use.
Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.
Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.
Availability, pack size, lead time, and pricing are confirmed through RFQ.
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