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CAS Number: 75706-12-6
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CAS Number
75706-12-6
PubChem CID
3899
Molecular Formula
C12H9F3N2O2
Molecular Weight
270.21 g/mol
Exact Mass
270.061612
InChIKey
VHOGYURTWQBHIL-UHFFFAOYSA-N
IUPAC Name
5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
SMILES String
CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F
Melting Point
165–166.5 °C
Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.
Structural features
Leflunomide (CAS 75706-12-6) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C12H9F3N2O2 and molecular weight 270. 21 g/mol.
Sourcing context
Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.
Research use context
Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.
Documentation needs
COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.
ChEMBL reports experimental activity evidence for: Dihydroorotate dehydrogenase (quinone), mitochondrial (Rattus norvegicus) — 2 assays; Cytochrome P450 1A2 (Homo sapiens) — 2 assays; Huntingtin (Homo sapiens) — 2 assays; Cytochrome P450 3A4 (Homo sapiens) — 3 assays; Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens) — 3 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.
Dihydroorotate dehydrogenase (quinone), mitochondrial
Rattus norvegicus · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 8.05
Experimental evidence source: ChEMBL
Cytochrome P450 1A2
Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 7.2
Experimental evidence source: ChEMBL
Huntingtin
Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 6.5
Experimental evidence source: ChEMBL
Cytochrome P450 3A4
Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 1 documents · best pChEMBL 6.2
Experimental evidence source: ChEMBL
Dihydroorotate dehydrogenase (quinone), mitochondrial
Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 3 documents · best pChEMBL 6.1
Experimental evidence source: ChEMBL
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Preliminary Safety Reference
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Safety Reference / SDS RequestCatalog navigation
Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.
Leflunomide is identified by CAS 75706-12-6, with molecular formula C12H9F3N2O2, molecular weight 270.21, InChIKey VHOGYURTWQBHIL-UHFFFAOYSA-N.
ChEMBL contains qualifying experimental assay evidence associated with Dihydroorotate dehydrogenase (quinone), mitochondrial, Cytochrome P450 1A2, Huntingtin, Cytochrome P450 3A4, Dihydroorotate dehydrogenase (quinone), mitochondrial. These records do not establish therapeutic efficacy or clinical use.
Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.
Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.
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