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Home/Compounds/CAS 2174-59-6
Formula C20H20O8MW 388.4Research-use catalog entryCOA/SDS by request

5-Demethylnobiletin

CAS Number: 2174-59-6

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Loading RDKit molecule structure...
InChIKey: DOFJNFPSMUCECH-UHFFFAOYSA-NC20H20O8 | MW 388.4

Chemical Absolute Identifiers

CAS Number

2174-59-6

PubChem CID

358832

Molecular Formula

C20H20O8

Molecular Weight

388.4 g/mol

Exact Mass

388.115818

InChIKey

DOFJNFPSMUCECH-UHFFFAOYSA-N

IUPAC Name

2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxychromen-4-one

SMILES String

COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C(=C(C(=C3O2)OC)OC)OC)O)OC

Physical Properties

Melting Point

145–146 °C

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

5-Demethylnobiletin (CAS 2174-59-6) is listed in the Advanced Chemicals portfolio, with molecular formula C20H20O8 and molecular weight 388. 40 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Heterocyclic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Cytochrome P450 3A4 (Homo sapiens) — 2 assays; Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Cytochrome P450 3A4

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 5

Experimental evidence source: ChEMBL

Tyrosyl-DNA phosphodiesterase 1

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Handling & Storage

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First Aid

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  • Rinse mouth with water.
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Fire Fighting

  • If necessary, wear a self-contained breathing apparatus for firefighting.

Accidental Release

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  • Avoid dust generation.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

5-Demethylnobiletin

Names & Synonyms

4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-Demethylnobiletin5-O-Demethylnobiletin2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-chromen-4-one5-O-Desmethylnobiletin
Show all synonyms
5-hydroxy-6,7,8,3',4'-pentamethoxyflavone5-Hydroxy-3',4',6,7,8-pentamethoxyflavone2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-onedesmethylnobiletin5-desmethylnobiletin5-demethyl nobiletin5-O-desmethyl nobiletin5-Desmethoxynobiletin (incorr.)5-O-Demethylnobiletin (Standard)s94215-Hydroxy 3?,4?,6,7,8-pentamethoxyflavoneAO-222/41148828Flavone, 5-hydroxy-3',4',6,7,8-pentamethoxy-2-(34-Dimethoxyphenyl)-5-hydroxy-678-trimethoxychromen-4-one
External Identifiers
DSSTOX SUBSTANCE ID: DTXSID60176134CHEMBL ID: CHEMBL75978CHEBI ID: CHEBI:175933UNII: OGE0V42MOTHMDB ID: HMDB0037571METABOLOMICS WORKBENCH ID: 24562WIKIDATA ID: Q27285643
Experimental Spectrum References
13C NMR Spectra
Literature & Patent References
DOI 10.1016/j.ejmech.2023.115791Discovery of anti-inflammatory natural flavonoids: Diverse scaffolds and promising leads for drug discovery.PMID 37683361Discovery of anti-inflammatory natural flavonoids: Diverse scaffolds and promising leads for drug discovery.DOI 10.1016/j.bmcl.2012.10.133Polymethoxyflavones as agents that prevent formation of cataract: nobiletin congeners show potent growth inhibitory effects in human lens epithelial cells.PMID 23199882Polymethoxyflavones as agents that prevent formation of cataract: nobiletin congeners show potent growth inhibitory effects in human lens epithelial cells.DOI 10.1021/jf3012163Structure-activity relationship of citrus polymethoxylated flavones and their inhibitory effects on Aspergillus niger.PMID 22500738Structure-activity relationship of citrus polymethoxylated flavones and their inhibitory effects on Aspergillus niger.DOI 10.1016/j.bmc.2011.10.001B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production.PMID 22047798B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

IsosinensetinCAS 17290-70-9
5-Hydroxy-6,7,3',4'-TetramethoxyflavoneCAS 21763-80-4
EupatilinCAS 22368-21-4
JaceosidinCAS 18085-97-7
NepetinCAS 520-11-6

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 17290-70-9IsosinensetinCAS 21763-80-45-Hydroxy-6,7,3',4'-TetramethoxyflavoneCAS 22368-21-4EupatilinCAS 18085-97-7JaceosidinCAS 520-11-6NepetinCAS 111974-69-7QuetiapineCAS 112574-44-4NitrofurazoneCAS 1161-94-0Phenamil MethanesulfonateCAS 1447-88-7HispidulinCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamate

RFQ questions for CAS 2174-59-6

What are the key identifiers for 5-Demethylnobiletin (CAS 2174-59-6)?

5-Demethylnobiletin is identified by CAS 2174-59-6, with molecular formula C20H20O8, molecular weight 388.4, InChIKey DOFJNFPSMUCECH-UHFFFAOYSA-N.

Does CAS 2174-59-6 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Cytochrome P450 3A4, Tyrosyl-DNA phosphodiesterase 1. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 2174-59-6?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for 5-Demethylnobiletin?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 2174-59-6 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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