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Home/Compounds/CAS 474645-27-7
Formula C39H67N5O7MW 718Research-use catalog entryCOA/SDS by request

Monomethylauristatin E

CAS Number: 474645-27-7

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Loading RDKit molecule structure...
InChIKey: DASWEROEPLKSEI-UIJRFTGLSA-NC39H67N5O7 | MW 718

Chemical Absolute Identifiers

CAS Number

474645-27-7

PubChem CID

11542188

Molecular Formula

C39H67N5O7

Molecular Weight

718 g/mol

Exact Mass

717.504049

InChIKey

DASWEROEPLKSEI-UIJRFTGLSA-N

IUPAC Name

(2S)-N-[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamide

SMILES String

CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC)C(C)C)C(C)C

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Monomethylauristatin E (CAS 474645-27-7) is listed in the Life Science portfolio, with molecular formula C39H67N5O7 and molecular weight 718. 00 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for life-science research and analytical workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

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Applications & Classification

Life Science ResearchResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Names & Synonyms / External Identifiers

Chemical Name

Monomethylauristatin E

Names & Synonyms

Monomethyl auristatin EMMAEMMAE peptideMMAE (Monomethyl auristatin E)Monomethyl auristatin E (GMP)
Show all synonyms
[3H]-VedotinMonomethyl auristatin E (MMAE)4Q5MMAE, monomethyl auristatin EMonomethyl auristatin E (Standard)MONOMETHYLAURISTATIN E [MI](S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1R,2R)-1-Hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheMonomethyl auristatin E (vedotin)?s7721MonoMethyl auristatin E(MMAE, vedotin)M5854
External Identifiers
EC NUMBER: 811-424-8DSSTOX SUBSTANCE ID: DTXSID101028844CHEMBL ID: CHEMBL2103835UNII: V7I58RC5EJNCI THESAURUS CODE: C122637WIKIDATA ID: Q6901739
Literature & Patent References
DOI 10.1021/acs.jmedchem.4c02232Development of ASGR-Mediated Hepatocyte-Targeting Cytotoxic Drug Conjugates with CTSB-Cleavable Linkers Incorporating Succinimide and Succinic Acid Monoamide.DOI 10.1021/acs.jmedchem.5c00847MMAE-Based Peptide-Drug Conjugates Targeting GPC3 for Precision Chemoradiotherapy in Hepatocellular Carcinoma.PMID 39918134Development of ASGR-Mediated Hepatocyte-Targeting Cytotoxic Drug Conjugates with CTSB-Cleavable Linkers Incorporating Succinimide and Succinic Acid Monoamide.PMID 40513081MMAE-Based Peptide-Drug Conjugates Targeting GPC3 for Precision Chemoradiotherapy in Hepatocellular Carcinoma.DOI 10.1016/j.bmcl.2023.129573PSMA-targeted small-molecule drug-conjugates with valine-citrulline and phosphoramidate cleavable linkers.DOI 10.1016/j.ejmech.2024.116709Antibody-drug conjugates for targeted cancer therapy: Recent advances in potential payloads.DOI 10.1016/j.ejmech.2024.116767In vitro and in vivo evaluation of Bombesin-MMAE conjugates for targeted tumour therapy.PMID 38052377PSMA-targeted small-molecule drug-conjugates with valine-citrulline and phosphoramidate cleavable linkers.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

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What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

L-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydro xy-1-methyl-CAS 160800-57-7
Monomethyl auristatin FCAS 745017-94-1
Demethyldolastatin 10CAS 203849-91-6
Auristatin FCAS 163768-50-1
VC-Pab-mmaeCAS 644981-35-1

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 160800-57-7L-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydro xy-1-methyl-CAS 745017-94-1Monomethyl auristatin FCAS 203849-91-6Demethyldolastatin 10CAS 163768-50-1Auristatin FCAS 644981-35-1VC-Pab-mmaeCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

RFQ questions for CAS 474645-27-7

What are the key identifiers for Monomethylauristatin E (CAS 474645-27-7)?

Monomethylauristatin E is identified by CAS 474645-27-7, with molecular formula C39H67N5O7, molecular weight 718, InChIKey DASWEROEPLKSEI-UIJRFTGLSA-N.

Can I request a COA for CAS 474645-27-7?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Monomethylauristatin E?

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Is CAS 474645-27-7 available for quotation?

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