- Package
- 1 g
- Purity
- 97%
- Price
- Request review
- Availability
- Shipping review required
- Delivery
- Shipping review required
CAS Number: 873054-44-5
Submit an RFQ to review pricing, availability, lead time, pack size, purity, COA, and supplier SDS for this catalog entry.
Available options
Shipping review is required before pricing or stock can be confirmed publicly. Shipping, duties, and documentation fees are confirmed before order acceptance.
CAS Number
873054-44-5
PubChem CID
16220172
Molecular Formula
C24H28N2O3
Molecular Weight
392.5 g/mol
Exact Mass
392.209993
InChIKey
PURKAOJPTOLRMP-UHFFFAOYSA-N
IUPAC Name
N-(2,4-ditert-butyl-5-hydroxyphenyl)-4-oxo-1H-quinoline-3-carboxamide
SMILES String
CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C
pKa
11.08
Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.
Structural features
Ivacaftor (CAS 873054-44-5) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C24H28N2O3 and molecular weight 392. 50 g/mol.
Sourcing context
Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.
Research use context
Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.
Documentation needs
COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.
ChEMBL reports experimental activity evidence for: Cystic fibrosis transmembrane conductance regulator (Homo sapiens) — 33 assays; 5-hydroxytryptamine receptor 2B (Homo sapiens) — 3 assays; Alpha-2A adrenergic receptor (Homo sapiens) — 3 assays; Cytochrome P450 2D6 (Homo sapiens) — 2 assays; Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.
Cystic fibrosis transmembrane conductance regulator
Homo sapiens · SINGLE PROTEIN · 33 qualifying assays · 11 documents · best pChEMBL 8.52
Experimental evidence source: ChEMBL
5-hydroxytryptamine receptor 2B
Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 1 documents
Experimental evidence source: ChEMBL
Alpha-2A adrenergic receptor
Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 1 documents
Experimental evidence source: ChEMBL
Cytochrome P450 2D6
Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents
Experimental evidence source: ChEMBL
Gamma-aminobutyric acid receptor subunit alpha-1
Rattus norvegicus · SINGLE PROTEIN · 2 qualifying assays · 1 documents
Experimental evidence source: ChEMBL
Safety and handling reference content is available through documentation requests.
For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.
Preliminary Safety Reference
For supplier-issued SDS or COA, submit a documentation request.
Safety Reference / SDS RequestCatalog navigation
Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.
Ivacaftor is identified by CAS 873054-44-5, with molecular formula C24H28N2O3, molecular weight 392.5, InChIKey PURKAOJPTOLRMP-UHFFFAOYSA-N.
ChEMBL contains qualifying experimental assay evidence associated with Cystic fibrosis transmembrane conductance regulator, 5-hydroxytryptamine receptor 2B, Alpha-2A adrenergic receptor, Cytochrome P450 2D6, Gamma-aminobutyric acid receptor subunit alpha-1. These records do not establish therapeutic efficacy or clinical use.
Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.
Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.
Availability, pack size, lead time, and pricing are confirmed through RFQ.
Submit the CAS number, quantity, purity requirement, and destination country for sourcing review.