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Home/Compounds/CAS 901119-35-5
Formula C23H26FN6O9PMW 580.5Research-use catalog entryCOA/SDS by request

Fostamatinib

CAS Number: 901119-35-5

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Loading RDKit molecule structure...
InChIKey: GKDRMWXFWHEQQT-UHFFFAOYSA-NC23H26FN6O9P | MW 580.5

Chemical Absolute Identifiers

CAS Number

901119-35-5

PubChem CID

11671467

Molecular Formula

C23H26FN6O9P

Molecular Weight

580.5 g/mol

Exact Mass

580.148292

InChIKey

GKDRMWXFWHEQQT-UHFFFAOYSA-N

IUPAC Name

[6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate

SMILES String

COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)N(COP(=O)(O)O)C(=O)C(C)(C)O4)n2)cc(OC)c1OC

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Fostamatinib (CAS 901119-35-5) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C23H26FN6O9P and molecular weight 580. 50 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Tyrosine-protein kinase SYK (Homo sapiens) — 7 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Tyrosine-protein kinase SYK

Homo sapiens · SINGLE PROTEIN · 7 qualifying assays · 4 documents · best pChEMBL 7.77

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Fostamatinib

Names & Synonyms

R-788 Free acidR788 FREE ACIDR-935788 Free acidR-788R935788 FREE ACID
Show all synonyms
R 7882H-Pyrido(3,2-b)-1,4-oxazin-3(4H)-one, 6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)-4-pyrimidinyl)amino)-2,2-dimethyl-4-((phosphonooxy)methyl)-(6-((5-FLUORO-2-((3,4,5-TRIMETHOXYPHENYL)AMINO)PYRIMIDIN-4-YL)AMINO)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-PYRIDO(3,2-B)(1,4)OXAZIN-4-YL)METHYL DIHYDROGEN PHOSPHATE(6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl)methyl dihydrogen phosphate[6-({5-Fluoro-2-[(3,4,5-Trimethoxyphenyl)amino]pyrimidin-4-Yl}amino)-2,2-Dimethyl-3-Oxo-2,3-Dihydro-4h-Pyrido[3,2-B][1,4]oxazin-4-Yl]methyl Dihydrogen Phosphatefostamatinibum(6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxopyrido(2,3-e)(1,4)oxazin-4-yl)methyl dihydrogen phosphate[6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[2,3-e][1,4]oxazin-4-yl]methyl dihydrogen phosphate2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-R788Fostamatinib (R788)TavalisseFostamatinib [USAN]Fostamatinib(R788)
External Identifiers
EC NUMBER: 618-473-2DSSTOX SUBSTANCE ID: DTXSID401009170CHEMBL ID: CHEMBL2103830UNII: SQ8A3S5101DRUGBANK ID: DB12010HMDB ID: HMDB0252469KEGG ID: D09347METABOLOMICS WORKBENCH ID: 153075NCI THESAURUS CODE: C95222RXCUI: 2044896WIKIDATA ID: Q5473550
Literature & Patent References
DOI 10.1016/j.ejmech.2022.114346Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators.DOI 10.1016/j.ejmech.2022.114551Dual-target Janus kinase (JAK) inhibitors: Comprehensive review on the JAK-based strategies for treating solid or hematological malignancies and immune-related diseases.DOI 10.1016/j.ejmech.2022.114742A decade of approved first-in-class small molecule orphan drugs: Achievements, challenges and perspectives.PMID 35483322Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators.PMID 35749986Dual-target Janus kinase (JAK) inhibitors: Comprehensive review on the JAK-based strategies for treating solid or hematological malignancies and immune-related diseases.PMID 36155354A decade of approved first-in-class small molecule orphan drugs: Achievements, challenges and perspectives.DOI 10.6019/CHEMBL4651402Screening of ~5500 FDA-approved drugs and clinical candidates for anti-SARS-CoV-2 activityDOI 10.1101/2020.04.21.054387Identification of potential treatments for COVID-19 through artificial intelligence-enabled phenomic analysis of human cells infected with SARS-CoV-2

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

Fostamatinib DisodiumCAS 914295-16-2
TamatinibCAS 841290-80-0
6-((2-Chloro-5-fluoro-4-pyrimidinyl)amino)-2,2-dimethyl-2H-pyrido(3,2-b)-1,4-oxazin-3(4H)-oneCAS 575484-83-2
N-(5-Chloropyridin-2-yl)-5-methoxy-2-nitrobenzamideCAS 280773-16-2
2-amino-N-(5-chloropyridin-2-yl)-5-methoxybenzamideCAS 280773-17-3

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 914295-16-2Fostamatinib DisodiumCAS 841290-80-0TamatinibCAS 120685-11-2MidostaurinCAS 443913-73-3VandetanibCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acidCAS 1018144-00-72-(3-Cyclopropyl-6-isopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 901119-35-5

What are the key identifiers for Fostamatinib (CAS 901119-35-5)?

Fostamatinib is identified by CAS 901119-35-5, with molecular formula C23H26FN6O9P, molecular weight 580.5, InChIKey GKDRMWXFWHEQQT-UHFFFAOYSA-N.

Does CAS 901119-35-5 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Tyrosine-protein kinase SYK. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 901119-35-5?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Fostamatinib?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 901119-35-5 available for quotation?

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