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Home/Compounds/CAS 66701-25-5
Formula C15H27N5O5MW 357.41Research-use catalog entryCOA/SDS by request

trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane

CAS Number: 66701-25-5

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Loading RDKit molecule structure...
InChIKey: LTLYEAJONXGNFG-DCAQKATOSA-NC15H27N5O5 | MW 357.41

Chemical Absolute Identifiers

CAS Number

66701-25-5

PubChem CID

123985

Molecular Formula

C15H27N5O5

Molecular Weight

357.41 g/mol

Exact Mass

357.201219

InChIKey

LTLYEAJONXGNFG-DCAQKATOSA-N

IUPAC Name

(2S,3S)-3-[[(2S)-1-[4-(diaminomethylideneamino)butylamino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid

SMILES String

CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(=O)O)C(=O)NCCCCNC(=N)N

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane (CAS 66701-25-5) is listed in the Advanced Chemicals portfolio, with molecular formula C15H27N5O5 and molecular weight 357. 41 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Heterocyclic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Papain (Carica papaya) — 5 assays; Procathepsin L (Homo sapiens) — 12 assays; Rhodesain (Trypanosoma brucei rhodesiense) — 10 assays; Cathepsin K (Homo sapiens) — 2 assays; Cathepsin B (Homo sapiens) — 16 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Papain

Carica papaya · SINGLE PROTEIN · 5 qualifying assays · 5 documents · best pChEMBL 8.7

Experimental evidence source: ChEMBL

Procathepsin L

Homo sapiens · SINGLE PROTEIN · 12 qualifying assays · 10 documents · best pChEMBL 8.64

Experimental evidence source: ChEMBL

Rhodesain

Trypanosoma brucei rhodesiense · SINGLE PROTEIN · 10 qualifying assays · 4 documents · best pChEMBL 8.51

Experimental evidence source: ChEMBL

Cathepsin K

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 8.4

Experimental evidence source: ChEMBL

Cathepsin B

Homo sapiens · SINGLE PROTEIN · 16 qualifying assays · 8 documents · best pChEMBL 8.34

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Names & Synonyms / External Identifiers

Chemical Name

trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane

Names & Synonyms

Proteinase inhibitor E 64e-64(2S,3S)-3-(((S)-1-((4-Guanidinobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxylic acidE 64E64
Show all synonyms
Thiol protease inhibitor(2S,3S)-3-[[(1S)-1-(4-guanidinobutylcarbamoyl)-3-methyl-butyl]carbamoyl]oxirane-2-carboxylic acid3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-(2S,3S)-oxiranecarboxylic acidE 64 (proteinase inhibitor)(2S,3S)-3-[[(S)-1-[(4-Guanidinobutyl)amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic Acid2-OXIRANECARBOXYLIC ACID, 3-((((1S)-1-(((4-((AMINOIMINOMETHYL)AMINO)BUTYL)AMINO)CARBONYL)-3-METHYLBUTYL)AMINO)CARBONYL)-, (2S,3S)-2-Oxiranecarboxylic acid, 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, (2S,3S)-Proteinase inhibitor E645-18-07-00006 (Beilstein Handbook Reference)PROTEINASE INHIBITOR E-643-[[1-[4-(diaminomethylideneamino)butylamino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acidOxiranecarboxylic acid, 3-(((1-(((4-((aminoiminomethyl)amino)butyl)amino)carbonyl)-3-methylbutyl)amino)carbonyl)-, (2S-(2-alpha,3-beta(R*)))-Oxiranecarboxylic acid, 3-(((1-(((4-((aminoiminomethyl)amino)butyl)amino)carbonyl)-3-methylbutyl)amino)carbonyl)-, (2S-(2alpha,3beta(R*)))-(L-3-trans-Carboxyoxiran-2-carbonyl)-L-leucyl-admat
External Identifiers
EC NUMBER: 613-978-4CHEMBL ID: CHEMBL374508CHEBI ID: CHEBI:30270UNII: R76F7856MVKEGG ID: C01341METABOLOMICS WORKBENCH ID: 51991
Literature & Patent References
DOI 10.1016/j.bmcl.2025.130133Isolation, synthesis and structure-activity relationships of gallotannin derivatives as cathepsin C inhibitor.DOI 10.1016/j.ejmech.2024.117109Nanomolar activity of coumarin-3-thiosemicarbazones targeting Trypanosoma cruzi cruzain and the T. brucei cathepsin L-like protease.PMID 39653622Nanomolar activity of coumarin-3-thiosemicarbazones targeting Trypanosoma cruzi cruzain and the T. brucei cathepsin L-like protease.PMID 39933615Isolation, synthesis and structure-activity relationships of gallotannin derivatives as cathepsin C inhibitor.DOI 10.1016/j.ejmech.2023.115969Blood-stage antimalarial activity, favourable metabolic stability and in vivo toxicity of novel piperazine linked 7-chloroquinoline-triazole conjugates.DOI 10.1016/j.ejmech.2024.116329Cathepsin B: The dawn of tumor therapy.DOI 10.1021/acs.jmedchem.3c02351Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors.DOI 10.1039/d3md00490bReinvestigation of diphenylmethylpiperazine analogues of pyrazine as new class of <i>Plasmodial</i> cysteine protease inhibitors for the treatment of malaria.

Documentation & Compliance Facts

Compliance Facts

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Text Reference Cues

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Non-public related references

E-64cCAS 76684-89-4
AloxistatinCAS 88321-09-9
(2R,3R)-3-(ethoxycarbonyl)oxirane-2-carboxylic acidCAS 93061-20-2
CA 074 methyl esterCAS 147859-80-1
1,1-Dimethylethyl N-((1S)-3-methyl-1-(((2R)-2-methyl-2-oxiranyl)carbonyl)butyl)carbamateCAS 247068-82-2

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 76684-89-4E-64cCAS 88321-09-9AloxistatinCAS 84-11-79,10-PhenanthrenedioneCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acidCAS 1018144-00-72-(3-Cyclopropyl-6-isopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

RFQ questions for CAS 66701-25-5

What are the key identifiers for trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane (CAS 66701-25-5)?

trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane is identified by CAS 66701-25-5, with molecular formula C15H27N5O5, molecular weight 357.41, InChIKey LTLYEAJONXGNFG-DCAQKATOSA-N.

Does CAS 66701-25-5 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Papain, Procathepsin L, Rhodesain, Cathepsin K, Cathepsin B. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 66701-25-5?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane?

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