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Home/Compounds/CAS 88321-09-9
Formula C17H30N2O5MW 342.4Research-use catalog entryCOA/SDS by request

Aloxistatin

CAS Number: 88321-09-9

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Loading RDKit molecule structure...
InChIKey: SRVFFFJZQVENJC-IHRRRGAJSA-NC17H30N2O5 | MW 342.4

Chemical Absolute Identifiers

CAS Number

88321-09-9

PubChem CID

65663

Molecular Formula

C17H30N2O5

Molecular Weight

342.4 g/mol

Exact Mass

342.215472

InChIKey

SRVFFFJZQVENJC-IHRRRGAJSA-N

IUPAC Name

ethyl (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylate

SMILES String

CCOC(=O)[C@@H]1[C@H](O1)C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Aloxistatin (CAS 88321-09-9) is listed in the Advanced Chemicals portfolio, with molecular formula C17H30N2O5 and molecular weight 342. 40 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Heterocyclic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Procathepsin L (Homo sapiens) — 3 assays; Calpain-1 catalytic subunit (Homo sapiens) — 3 assays; Cathepsin B (Homo sapiens) — 2 assays; Papain (Carica papaya) — 3 assays; Protein deacetylase HDAC6 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Procathepsin L

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 3 documents · best pChEMBL 7.47

Experimental evidence source: ChEMBL

Calpain-1 catalytic subunit

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 2 documents · best pChEMBL 5.4

Experimental evidence source: ChEMBL

Cathepsin B

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 4.84

Experimental evidence source: ChEMBL

Papain

Carica papaya · SINGLE PROTEIN · 3 qualifying assays · 1 documents · best pChEMBL 4.28

Experimental evidence source: ChEMBL

Protein deacetylase HDAC6

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Handling & Storage

  • Keep container tightly closed and dry.
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PPE

Respiratory protection if needed

First Aid

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Stability / Reactivity

  • Reactivity and reaction.
  • Carbon monoxide, carbon dioxide, nitrogen oxides.

Disposal

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Fire Fighting

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Accidental Release

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Preliminary Safety Reference

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Names & Synonyms / External Identifiers

Chemical Name

Aloxistatin

Names & Synonyms

E-64DLoxistatinE 64dAloxistatinaAloxistatine
Show all synonyms
AloxistatinumE 64c ethyl esterE64dEthyl (+)-(2S,3S)-2,3-epoxy-N-((S)-1-(isopentylcarbamoyl)-3-methylbutyl)succinamateethyl (2S,3S)-3-(((2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxylateprotease inhibitor E64dEpoxysuccinyl-leucylamide(3-methyl)butane ethyl esterloxistatin, (2S-(2alpha,3beta(R*)))-Ethyl 3-(3-methyl-1-(3-methylbutylcarbamoyl)butylcarbamoyl)-2-oxiranecarboxylateAloxistatin [INN]ESTE-64-d2-Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-ethyl (2S,3S)-3-(((S)-1-(isopentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxylate
External Identifiers
EC NUMBER: 635-831-3DSSTOX SUBSTANCE ID: DTXSID00904150CHEMBL ID: CHEMBL63440CHEBI ID: CHEBI:101381UNII: L5W337AOURDRUGBANK ID: DB18145NCI THESAURUS CODE: C76907WIKIDATA ID: Q27177634
Literature & Patent References
DOI 10.1021/acs.jmedchem.4c02468From N-0385 to N-0920: Unveiling a Host-Directed Protease Inhibitor with Picomolar Antiviral Efficacy against Prevalent SARS-CoV-2 Variants.PMID 40163818From N-0385 to N-0920: Unveiling a Host-Directed Protease Inhibitor with Picomolar Antiviral Efficacy against Prevalent SARS-CoV-2 Variants.DOI 10.1016/j.ejmech.2023.115923Targeting SARS-CoV-2 entry processes: The promising potential and future of host-targeted small-molecule inhibitors.DOI 10.1016/j.ejmech.2023.116117Targeting autophagy drug discovery: Targets, indications and development trends.DOI 10.1016/j.ejmech.2024.116128Peptidomimetics as potent dual SARS-CoV-2 cathepsin-L and main protease inhibitors: In silico design, synthesis and pharmacological characterization.DOI 10.1016/j.ejmech.2024.116329Cathepsin B: The dawn of tumor therapy.DOI 10.1021/acs.jmedchem.3c02351Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors.PMID 37981443Targeting SARS-CoV-2 entry processes: The promising potential and future of host-targeted small-molecule inhibitors.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

E-64cCAS 76684-89-4
trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butaneCAS 66701-25-5
(2R,3R)-3-(ethoxycarbonyl)oxirane-2-carboxylic acidCAS 93061-20-2
Ethyl 2,3-epoxybutyrateCAS 19780-35-9
Ethyl 3-phenylglycidateCAS 121-39-1

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 76684-89-4E-64cCAS 66701-25-5trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butaneCAS 93061-20-2(2R,3R)-3-(ethoxycarbonyl)oxirane-2-carboxylic acidCAS 179324-69-7BortezomibCAS 4008-48-4NitroxolineCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acidCAS 1018125-49-92-(3-Cyclopropyl-6-ethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acidCAS 1018128-07-8Isopropyl 4-chloro-2-methylquinoline-6-carboxylateCAS 1018142-22-76-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

RFQ questions for CAS 88321-09-9

What are the key identifiers for Aloxistatin (CAS 88321-09-9)?

Aloxistatin is identified by CAS 88321-09-9, with molecular formula C17H30N2O5, molecular weight 342.4, InChIKey SRVFFFJZQVENJC-IHRRRGAJSA-N.

Does CAS 88321-09-9 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Procathepsin L, Calpain-1 catalytic subunit, Cathepsin B, Papain, Protein deacetylase HDAC6. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 88321-09-9?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Aloxistatin?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 88321-09-9 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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