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Home/Compounds/CAS 961-29-5
Formula C15H12O4MW 256.25Research-use catalog entryCOA/SDS by request

Isoliquiritigenin

CAS Number: 961-29-5

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Loading RDKit molecule structure...
InChIKey: DXDRHHKMWQZJHT-FPYGCLRLSA-NC15H12O4 | MW 256.25

Chemical Absolute Identifiers

CAS Number

961-29-5

PubChem CID

638278

Molecular Formula

C15H12O4

Molecular Weight

256.25 g/mol

Exact Mass

256.073559

InChIKey

DXDRHHKMWQZJHT-FPYGCLRLSA-N

IUPAC Name

(E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one

SMILES String

C1=CC(=CC=C1/C=C/C(=O)C2=C(C=C(C=C2)O)O)O

Physical Properties

Melting Point

2–204 °C

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Isoliquiritigenin (CAS 961-29-5) is listed in the Advanced Chemicals portfolio, with molecular formula C15H12O4 and molecular weight 256. 25 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Organic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Matrilysin (Homo sapiens) — 2 assays; Matrix metalloproteinase-9 (Homo sapiens) — 5 assays; 72 kDa type IV collagenase (Homo sapiens) — 2 assays; Collagenase 3 (Homo sapiens) — 2 assays; Interstitial collagenase (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Matrilysin

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 8.1

Experimental evidence source: ChEMBL

Matrix metalloproteinase-9

Homo sapiens · SINGLE PROTEIN · 5 qualifying assays · 2 documents · best pChEMBL 8

Experimental evidence source: ChEMBL

72 kDa type IV collagenase

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 8

Experimental evidence source: ChEMBL

Collagenase 3

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 7.85

Experimental evidence source: ChEMBL

Interstitial collagenase

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 7.8

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Isoliquiritigenin

Names & Synonyms

trihydroxychalcone6'-deoxychalcone2',4',4-TrihydroxychalconeChalcone, 2',4,4'-trihydroxy-GU 17
Show all synonyms
trans-2',4,4'-trihydroxychalcone2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-, (E)-(E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-propenone(E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propene-1-one2',4,4'-Trihydroxychalcone4,2',4'-TrihydroxychalconeIsoliquiritigen(2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one(2E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-42'4'-trihydroxychalconeAcrylophenone, 2',4'-dihydroxy-3-(p-hydroxyphenyl)-
External Identifiers
EC NUMBER: 237-316-5EC NUMBER: 677-489-8DSSTOX SUBSTANCE ID: DTXSID2022466CHEMBL ID: CHEMBL129795CHEBI ID: CHEBI:310312UNII: B9CTI9GB8FDRUGBANK ID: DB03285HMDB ID: HMDB0037316KEGG ID: C08650METABOLOMICS WORKBENCH ID: 26572WIKIDATA ID: Q3155537GU-17
Experimental Spectrum References
13C NMR Spectra1D NMR SpectraATR-IR Spectra — Forensic Spectral ResearchRaman Spectra — Forensic Spectral Research
Literature & Patent References
DOI 10.1016/j.bmc.2025.118110Ligustrazine as a multitarget scaffold in drug design and discovery.DOI 10.1016/j.ejmech.2024.117012Understanding the synergistic sensitization of natural products and antibiotics: An effective strategy to combat MRSA.PMID 39509947Understanding the synergistic sensitization of natural products and antibiotics: An effective strategy to combat MRSA.PMID 39955802Ligustrazine as a multitarget scaffold in drug design and discovery.DOI 10.1016/j.ejmech.2024.116836Discovery and optimization of isoliquiritigenin as a death-associated protein kinase 1 inhibitor.DOI 10.1021/acs.jmedchem.4c00537Natural Product-Inspired Dopamine Receptor Ligands.DOI 10.1021/acs.jnatprod.4c00690Antimicrobial Dihydroflavonols and Isoflavans Isolated from the Root Bark of <i>Dalbergia gloveri</i>.PMID 39038276Natural Product-Inspired Dopamine Receptor Ligands.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

2',4'-DihydroxychalconeCAS 1776-30-3
ButeinCAS 487-52-5
2',4,4',6'-TetrahydroxychalconeCAS 73692-50-9
IsobavachalconeCAS 20784-50-3
Pinocembrin chalconeCAS 4197-97-1

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 1776-30-32',4'-DihydroxychalconeCAS 487-52-5ButeinCAS 73692-50-92',4,4',6'-TetrahydroxychalconeCAS 20784-50-3IsobavachalconeCAS 4197-97-1Pinocembrin chalconeCAS 520-36-5ApigeninCAS 65646-68-6FenretinideCAS 21829-25-4NifedipineCAS 77-52-1(+)-Ursolic AcidCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamate

RFQ questions for CAS 961-29-5

What are the key identifiers for Isoliquiritigenin (CAS 961-29-5)?

Isoliquiritigenin is identified by CAS 961-29-5, with molecular formula C15H12O4, molecular weight 256.25, InChIKey DXDRHHKMWQZJHT-FPYGCLRLSA-N.

Does CAS 961-29-5 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Matrilysin, Matrix metalloproteinase-9, 72 kDa type IV collagenase, Collagenase 3, Interstitial collagenase. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 961-29-5?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Isoliquiritigenin?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 961-29-5 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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