CAS 1128269-66-8 SDS Request & Safety Reference

Preliminary reference disclaimer

This preliminary safety reference is generated from structured MolGraph catalog fields and public reference-style data. It is not a supplier-issued Safety Data Sheet and should not be used as a substitute for supplier-issued documentation, workplace safety review, transport classification, or regulatory compliance decisions. For supplier SDS or COA, submit a documentation request through MolGraph.

Documentation status

Preliminary safety reference

Available

Supplier-issued SDS

Available by request

COA

Available by RFQ / lot confirmation

Transport classification

Requires shipment review

Identity

CAS Number

1128269-66-8

Chemical name

2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)-5-(trifluoromethyl)pyridine

Molecular formula

C12H14BF4NO2

Molecular weight

291.05 g/mol

Synonyms

2-FLUORO-5-(TRIFLUOROMETHYL)-PYRIDINE-3-BORONIC ACID PINACOL ESTER; G71316; Z2049751679; 2-fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridine

InChIKey

CVCZGFALKKFEQE-UHFFFAOYSA-N

PubChem CID

67159100

Hazard / GHS Reference

GHS Pictograms

Catalog reference cue; confirm supplier documentation before use.

Handling & PPE

Handle in a well-ventilated area or fume hood.
Avoid inhalation, ingestion, and skin/eye contact.
Keep container tightly closed in a dry and well-ventilated place.
Store away from incompatible materials.
Practice good industrial hygiene and safety procedures.
Use appropriate PPE such as lab coat, compatible gloves, and eye protection.
Wear respiratory protection if ventilation is inadequate or if there is a risk of dust/aerosol exposure.
Ensure eye wash stations and safety showers are available.
Gloves should be inspected prior to use. Use proper glove removal technique.

First Aid / Accidental Release

In case of inhalation, move to fresh air. If not breathing, give artificial respiration.
In case of skin contact, wash off with soap and plenty of water.
In case of eye contact, rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
If swallowed, rinse mouth. Do NOT induce vomiting.
In case of exposure, seek medical attention according to institutional procedures.
For spills, avoid dust or aerosol generation.
Ensure adequate ventilation during cleanup.
Collect spilled material using trained-lab procedures and appropriate tools.
Place in suitable, closed containers for disposal.

Firefighting / Stability

Use extinguishing media appropriate for the surrounding fire.
Wear self-contained breathing apparatus for firefighting if necessary.
Wear full protective firefighting gear.
Keep containers cool with water spray if exposed to fire.
Avoid inhalation of hazardous combustion products.
This material is considered stable under recommended storage conditions.
Avoid strong oxidizing agents.
Avoid strong acids and strong bases.
Hazardous decomposition products may include carbon oxides, nitrogen oxides, hydrogen fluoride, and boron oxides.

Physical and Chemical Reference

Appearance

white to off-white solid

Catalog reference value; verify against supplier SDS before use.

Physical State

solid

Catalog reference value; verify against supplier SDS before use.

Melting Point

95.0 °C

Catalog reference value; verify against supplier SDS before use.

Boiling Point

280.0 °C

Catalog reference value; verify against supplier SDS before use.

Density

1.4 g/cm³

Catalog reference value; verify against supplier SDS before use.

Water Solubility

insoluble

Catalog reference value; verify against supplier SDS before use.

Flash Point

145.0 °C

Catalog reference value; verify against supplier SDS before use.

Vapor Pressure

Estimated value, unit not specified

Catalog reference value; verify against supplier SDS before use.

Autoignition Temp

420.0 °C

Catalog reference value; verify against supplier SDS before use.

Transport / Shipment Review

HS Code

293339

Preliminary catalog cue; verify before compliance decisions.

GHS Pictograms

Preliminary catalog cue; verify before compliance decisions.

Compliance

standard-ruo

Preliminary catalog cue; verify before compliance decisions.

Registration Status

DSL: pending; AICS: pending; ENCS: pending; ICSR: pending; TSCA: pending; IECSC: pending; INSQR: pending; REACH: pending; K-REACH: pending; SEA_Regulatory: pending

Registration values are catalog reference status cues and may require jurisdiction-specific review.

Shipment review

Shipment details require review before fulfillment.

Transport classification must be confirmed using supplier SDS and shipment documentation before dispatch.

Transport classification must be confirmed using supplier SDS and shipment documentation before dispatch.

Need supplier documentation?

Request through MolGraph:

Supplier-issued SDS
COA
Purity and pack size confirmation
Availability and lead time review
Shipment documentation review

Catalog-Specific Reference Cues

This compound is a fluorinated pyridine derivative featuring a trifluoromethyl group and a pinacol boronate ester. It serves as a versatile building block in organic synthesis, particularly for creating complex fluorinated molecules for research-use applications.
2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)-5-(trifluoromethyl)pyridine, identified by CAS 1128269-66-8, is a sophisticated organic compound with the molecular formula C12H14BF4NO2 and a molecular weight of 291.05. It incorporates a pyridine core substituted with a fluorine atom, a trifluoromethyl group, and a 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl (pinacol boronate) moiety. This structure makes it a valuable functionalized intermediate for advanced synthetic chemistry, enabling the introduction of both fluorine and trifluoromethyl groups, as well as facilitating cross-coupling reactions via the boronate ester.
Primarily used as a versatile building block in organic synthesis, especially for the preparation of fluorinated pyridine derivatives. It is particularly useful in Suzuki-Miyaura cross-coupling reactions for forming carbon-carbon bonds, enabling the construction of complex molecules for pharmaceutical and agrochemical research.

Related catalog entries

2-Fluoro-6-(trifluoromethyl)pyridine-4-boronic acid pinacol esterView related compound →3-Fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridineView related compound →6-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridineView related compound →2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridineView related compound →

Identity

CAS Number

1128269-66-8

Chemical name

2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)-5-(trifluoromethyl)pyridine

Molecular formula

C12H14BF4NO2

Molecular weight

291.05 g/mol

Synonyms

2-FLUORO-5-(TRIFLUOROMETHYL)-PYRIDINE-3-BORONIC ACID PINACOL ESTER; G71316; Z2049751679; 2-fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridine

InChIKey

CVCZGFALKKFEQE-UHFFFAOYSA-N

PubChem CID

67159100

Handling & PPE

Handle in a well-ventilated area or fume hood.
Avoid inhalation, ingestion, and skin/eye contact.
Keep container tightly closed in a dry and well-ventilated place.
Store away from incompatible materials.
Practice good industrial hygiene and safety procedures.
Use appropriate PPE such as lab coat, compatible gloves, and eye protection.
Wear respiratory protection if ventilation is inadequate or if there is a risk of dust/aerosol exposure.
Ensure eye wash stations and safety showers are available.
Gloves should be inspected prior to use. Use proper glove removal technique.

First Aid / Accidental Release

In case of inhalation, move to fresh air. If not breathing, give artificial respiration.
In case of skin contact, wash off with soap and plenty of water.
In case of eye contact, rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
If swallowed, rinse mouth. Do NOT induce vomiting.
In case of exposure, seek medical attention according to institutional procedures.
For spills, avoid dust or aerosol generation.
Ensure adequate ventilation during cleanup.
Collect spilled material using trained-lab procedures and appropriate tools.
Place in suitable, closed containers for disposal.

Firefighting / Stability

Use extinguishing media appropriate for the surrounding fire.
Wear self-contained breathing apparatus for firefighting if necessary.
Wear full protective firefighting gear.
Keep containers cool with water spray if exposed to fire.
Avoid inhalation of hazardous combustion products.
This material is considered stable under recommended storage conditions.
Avoid strong oxidizing agents.
Avoid strong acids and strong bases.
Hazardous decomposition products may include carbon oxides, nitrogen oxides, hydrogen fluoride, and boron oxides.

Physical and Chemical Reference

Appearance

white to off-white solid

Catalog reference value; verify against supplier SDS before use.

Physical State

solid

Catalog reference value; verify against supplier SDS before use.

Melting Point

95.0 °C

Catalog reference value; verify against supplier SDS before use.

Boiling Point

280.0 °C

Catalog reference value; verify against supplier SDS before use.

Density

1.4 g/cm³

Catalog reference value; verify against supplier SDS before use.

Water Solubility

insoluble

Catalog reference value; verify against supplier SDS before use.

Flash Point

145.0 °C

Catalog reference value; verify against supplier SDS before use.

Vapor Pressure

Estimated value, unit not specified

Catalog reference value; verify against supplier SDS before use.

Autoignition Temp

420.0 °C

Catalog reference value; verify against supplier SDS before use.

Transport / Shipment Review

HS Code

293339

Preliminary catalog cue; verify before compliance decisions.

GHS Pictograms

Preliminary catalog cue; verify before compliance decisions.

Compliance

standard-ruo

Preliminary catalog cue; verify before compliance decisions.

Registration Status

DSL: pending; AICS: pending; ENCS: pending; ICSR: pending; TSCA: pending; IECSC: pending; INSQR: pending; REACH: pending; K-REACH: pending; SEA_Regulatory: pending

Registration values are catalog reference status cues and may require jurisdiction-specific review.

Shipment review

Shipment details require review before fulfillment.

Transport classification must be confirmed using supplier SDS and shipment documentation before dispatch.

Transport classification must be confirmed using supplier SDS and shipment documentation before dispatch.

Catalog-Specific Reference Cues

This compound is a fluorinated pyridine derivative featuring a trifluoromethyl group and a pinacol boronate ester. It serves as a versatile building block in organic synthesis, particularly for creating complex fluorinated molecules for research-use applications.
2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)-5-(trifluoromethyl)pyridine, identified by CAS 1128269-66-8, is a sophisticated organic compound with the molecular formula C12H14BF4NO2 and a molecular weight of 291.05. It incorporates a pyridine core substituted with a fluorine atom, a trifluoromethyl group, and a 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl (pinacol boronate) moiety. This structure makes it a valuable functionalized intermediate for advanced synthetic chemistry, enabling the introduction of both fluorine and trifluoromethyl groups, as well as facilitating cross-coupling reactions via the boronate ester.
Primarily used as a versatile building block in organic synthesis, especially for the preparation of fluorinated pyridine derivatives. It is particularly useful in Suzuki-Miyaura cross-coupling reactions for forming carbon-carbon bonds, enabling the construction of complex molecules for pharmaceutical and agrochemical research.

CAS 1128269-66-8 Safety Reference and Supplier SDS Request

Documentation status

Identity

Hazard / GHS Reference

Handling & PPE

First Aid / Accidental Release

Firefighting / Stability

Physical and Chemical Reference

Transport / Shipment Review

CAS 1128269-66-8 Safety Reference and Supplier SDS Request

Documentation status

Identity

Hazard / GHS Reference

Handling & PPE

First Aid / Accidental Release

Firefighting / Stability

Physical and Chemical Reference

Transport / Shipment Review