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Home/Compounds/CAS 153436-54-5
Formula C16H14BrN3O2MW 360.2Research-use catalog entryCOA/SDS by request

PD-153035

CAS Number: 153436-54-5

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84% Reflux 通用方法:将4-氯喹唑啉(1mmol)溶于回流的2-丙醇(20ml)中,逐滴加入取代的苯胺(1mmol)。 将反应混合物回流3-4小时,直至反应完成,如TLC所示。 滤出形成的沉淀,用2-丙醇(10ml)洗涤,然后用乙
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Loading RDKit molecule structure...
InChIKey: LSPANGZZENHZNJ-UHFFFAOYSA-NC16H14BrN3O2 | MW 360.2

Chemical Absolute Identifiers

CAS Number

153436-54-5

PubChem CID

4705

Molecular Formula

C16H14BrN3O2

Molecular Weight

360.2 g/mol

Exact Mass

359.02694

InChIKey

LSPANGZZENHZNJ-UHFFFAOYSA-N

IUPAC Name

N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine

SMILES String

COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

PD-153035 (CAS 153436-54-5) is listed in the Advanced Chemicals portfolio, with molecular formula C16H14BrN3O2 and molecular weight 360. 20 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Heterocyclic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Epidermal growth factor receptor (Homo sapiens) — 48 assays; Cyclin-G-associated kinase (Homo sapiens) — 2 assays; Cytochrome P450 2C9 (Homo sapiens) — 2 assays; Vascular endothelial growth factor receptor 2 (Homo sapiens) — 3 assays; Broad substrate specificity ATP-binding cassette transporter ABCG2 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Epidermal growth factor receptor

Homo sapiens · SINGLE PROTEIN · 48 qualifying assays · 39 documents · best pChEMBL 10.6

Experimental evidence source: ChEMBL

Cyclin-G-associated kinase

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 7.54

Experimental evidence source: ChEMBL

Cytochrome P450 2C9

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 6.4

Experimental evidence source: ChEMBL

Vascular endothelial growth factor receptor 2

Homo sapiens · SINGLE PROTEIN · 3 qualifying assays · 1 documents · best pChEMBL 5.83

Experimental evidence source: ChEMBL

Broad substrate specificity ATP-binding cassette transporter ABCG2

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents · best pChEMBL 5.76

Experimental evidence source: ChEMBL

Safety & Handling

Handling & Storage

  • Keep container tightly closed and dry.
  • Store in a well-ventilated place.
  • Avoid contact with skin and eyes.

PPE

Respiratory protection if needed

First Aid

  • Do not give anything to an unconscious person.
  • Rinse mouth with water.

Stability / Reactivity

  • Reactivity.
  • Carbon monoxide, carbon dioxide, hydrogen bromide, nitrogen oxides.

Disposal

  • Waste product: Dispose of remaining and non-recyclable solutions to a licensed company.
  • Contact a professional agency with waste disposal license to handle this substance.
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Fire Fighting

  • If necessary, wear a self-contained breathing apparatus for firefighting.

Accidental Release

  • Do not generate dust when collecting and disposing.
  • Sweep and shovel up.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

For supplier-issued SDS or COA, submit a documentation request.

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Names & Synonyms / External Identifiers

Chemical Name

PD-153035

Names & Synonyms

SU 52714-(3-bromophenylamino)-6,7-dimethoxyquinazoline(3-Bromophenyl)(6,7-dimethoxyquinazolin-4-yl)amineGI 230329A4-QUINAZOLINAMINE, N-(3-BROMOPHENYL)-6,7-DIMETHOXY-
Show all synonyms
pd 1530354-(3-BROMOANILINO)-6,7-DIMETHOXYQUINAZOLINEAG 1517N-(3-BROMOPHENYL)-6,7-DIMETHOXY-4-QUINAZOLINAMINEN-(3-bromophenyl)-6,7-dimethoxy-quinazolin-4-amineAG-1517 HCls6546SDCCGSBI-0634834.P002PD 153035(AG-1517)?4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline4-(3-Bromoanilino)-6,7-dimethoxyquinazoline hydrochlorideInChI=1/C16H14BrN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
External Identifiers
EC NUMBER: 802-811-2DSSTOX SUBSTANCE ID: DTXSID80165328CHEMBL ID: CHEMBL29197CHEBI ID: CHEBI:91076UNII: TC62B68RSLNCI THESAURUS CODE: C1787WIKIDATA ID: Q27163047Tocris-1037
Experimental Spectrum References
13C NMR Spectra1D NMR Spectra
Literature & Patent References
DOI 10.1016/j.bmcl.2025.130214Synthesis and biological evaluation of novel 4-Arylaminoquinolines derivatives as EGFR/HDAC inhibitors.PMID 40164393Synthesis and biological evaluation of novel 4-Arylaminoquinolines derivatives as EGFR/HDAC inhibitors.DOI 10.1016/j.bmc.2024.117902Recent advances in the design of small molecular drugs with acrylamides covalent warheads.DOI 10.1016/j.isci.2024.108907Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnelPMID 38318365Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnelPMID 39236467Recent advances in the design of small molecular drugs with acrylamides covalent warheads.DOI 10.6019/EOS300108ECBD screening data for assay EOS300108DOI 10.6019/CHEMBL4651402Screening of ~5500 FDA-approved drugs and clinical candidates for anti-SARS-CoV-2 activity

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
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  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

PD-153035 hydrochlorideCAS 183322-45-4
6,7-dimethoxy-N-phenylquinazolin-4-amineCAS 21561-09-1
4-(3-Hydroxyanilino)-6,7-DimethoxyquinazolineCAS 211555-08-7
N-(3,4-dimethoxyphenyl)-6,7-dimethoxyquinazolin-4-amineCAS 202475-65-8
Whi-P154CAS 211555-04-3

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 183322-45-4PD-153035 hydrochlorideCAS 21561-09-16,7-dimethoxy-N-phenylquinazolin-4-amineCAS 211555-08-74-(3-Hydroxyanilino)-6,7-DimethoxyquinazolineCAS 202475-65-8N-(3,4-dimethoxyphenyl)-6,7-dimethoxyquinazolin-4-amineCAS 211555-04-3Whi-P154CAS 13790-39-14-Chloro-6,7-dimethoxyquinazolineCAS 319460-85-0AxitinibCAS 443913-73-3VandetanibCAS 50-65-7NiclosamideCAS 690206-97-4CB-676475

RFQ questions for CAS 153436-54-5

What are the key identifiers for PD-153035 (CAS 153436-54-5)?

PD-153035 is identified by CAS 153436-54-5, with molecular formula C16H14BrN3O2, molecular weight 360.2, InChIKey LSPANGZZENHZNJ-UHFFFAOYSA-N.

Does CAS 153436-54-5 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Epidermal growth factor receptor, Cyclin-G-associated kinase, Cytochrome P450 2C9, Vascular endothelial growth factor receptor 2, Broad substrate specificity ATP-binding cassette transporter ABCG2. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 153436-54-5?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for PD-153035?

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Is CAS 153436-54-5 available for quotation?

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