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Home/Compounds/CAS 21561-09-1
Formula C16H15N3O2MW 281.31Research-use catalog entryCOA/SDS by request

6,7-dimethoxy-N-phenylquinazolin-4-amine

CAS Number: 21561-09-1

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Loading RDKit molecule structure...
InChIKey: MJKCGAHOCZLYDG-UHFFFAOYSA-NC16H15N3O2 | MW 281.31

Chemical Absolute Identifiers

CAS Number

21561-09-1

PubChem CID

3798

Molecular Formula

C16H15N3O2

Molecular Weight

281.31 g/mol

Exact Mass

281.116427

InChIKey

MJKCGAHOCZLYDG-UHFFFAOYSA-N

SMILES String

COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC=C3)OC

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

6,7-dimethoxy-N-phenylquinazolin-4-amine (CAS 21561-09-1) is listed in the Advanced Chemicals portfolio, with molecular formula C16H15N3O2 and molecular weight 281. 31 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Heterocyclic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Epidermal growth factor receptor (Homo sapiens) — 5 assays; Vascular endothelial growth factor receptor 2 (Homo sapiens) — 2 assays; Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens) — 2 assays; Tyrosine-protein kinase JAK2 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Epidermal growth factor receptor

Homo sapiens · SINGLE PROTEIN · 5 qualifying assays · 4 documents · best pChEMBL 7.54

Experimental evidence source: ChEMBL

Vascular endothelial growth factor receptor 2

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 5.16

Experimental evidence source: ChEMBL

Receptor-type tyrosine-protein kinase FLT3

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Tyrosine-protein kinase JAK2

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Handling & Storage

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Stability / Reactivity

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Preliminary Safety Reference

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Names & Synonyms / External Identifiers

Chemical Name

6,7-dimethoxy-N-phenylquinazolin-4-amine

Names & Synonyms

4-Quinazolinamine, 6,7-dimethoxy-N-phenyl-4-Phenylamino-6,7-dimethoxyquinazoline6,7-dimethoxy-N-phenyl-4-quinazolinamineOprea1_506594WHI-P258?
Show all synonyms
s65216,7-dimethoxy-N-phenyl-quinazolin-4-amine4-(phenyl)-amino-6,7-dimethoxy-quinazolineW2934
External Identifiers
DSSTOX SUBSTANCE ID: DTXSID80274409CHEMBL ID: CHEMBL94191WIKIDATA ID: Q82003768
Experimental Spectrum References
13C NMR Spectra
Literature & Patent References
DOI 10.1021/acs.jmedchem.8b01714Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations.PMID 30742435Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations.DOI 10.1016/j.bmcl.2016.03.100Anilinoquinazoline inhibitors of the RET kinase domain-Elaboration of the 7-position.PMID 27086121Anilinoquinazoline inhibitors of the RET kinase domain-Elaboration of the 7-position.DOI 10.1016/j.bmc.2014.01.044Synthesis, biological evaluation and molecular modelling studies of 4-anilinoquinazoline derivatives as protein kinase inhibitors.PMID 24530227Synthesis, biological evaluation and molecular modelling studies of 4-anilinoquinazoline derivatives as protein kinase inhibitors.DOI 10.1016/j.ejmech.2012.07.036Synthesis, characterization, screening and docking analysis of 4-anilinoquinazoline derivatives as tyrosine kinase inhibitors.PMID 22867529Synthesis, characterization, screening and docking analysis of 4-anilinoquinazoline derivatives as tyrosine kinase inhibitors.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

Whi-p131CAS 202475-60-3
N-(3,4-dimethoxyphenyl)-6,7-dimethoxyquinazolin-4-amineCAS 202475-65-8
PD-153035CAS 153436-54-5
4-(3-Hydroxyanilino)-6,7-DimethoxyquinazolineCAS 211555-08-7
PD-153035 hydrochlorideCAS 183322-45-4

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 202475-60-3Whi-p131CAS 202475-65-8N-(3,4-dimethoxyphenyl)-6,7-dimethoxyquinazolin-4-amineCAS 153436-54-5PD-153035CAS 211555-08-74-(3-Hydroxyanilino)-6,7-DimethoxyquinazolineCAS 183322-45-4PD-153035 hydrochlorideCAS 1032900-25-6CeritinibCAS 120685-11-2MidostaurinCAS 146535-11-76,7-Dimethoxy-3-phenylquinoxalineCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamateCAS 1005174-17-3(E)-3-(2-Propyl-6-(trifluoromethyl)pyridin-3-yl)acrylic acid

RFQ questions for CAS 21561-09-1

What are the key identifiers for 6,7-dimethoxy-N-phenylquinazolin-4-amine (CAS 21561-09-1)?

6,7-dimethoxy-N-phenylquinazolin-4-amine is identified by CAS 21561-09-1, with molecular formula C16H15N3O2, molecular weight 281.31, InChIKey MJKCGAHOCZLYDG-UHFFFAOYSA-N.

Does CAS 21561-09-1 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Epidermal growth factor receptor, Vascular endothelial growth factor receptor 2, Receptor-type tyrosine-protein kinase FLT3, Tyrosine-protein kinase JAK2. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 21561-09-1?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for 6,7-dimethoxy-N-phenylquinazolin-4-amine?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 21561-09-1 available for quotation?

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