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Home/Compounds/CAS 202475-60-3
Formula C16H15N3O3MW 297.31Research-use catalog entryCOA/SDS by request

Whi-p131

CAS Number: 202475-60-3

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Loading RDKit molecule structure...
InChIKey: HOZUXBLMYUPGPZ-UHFFFAOYSA-NC16H15N3O3 | MW 297.31

Chemical Absolute Identifiers

CAS Number

202475-60-3

PubChem CID

3794

Molecular Formula

C16H15N3O3

Molecular Weight

297.31 g/mol

Exact Mass

297.111341

InChIKey

HOZUXBLMYUPGPZ-UHFFFAOYSA-N

IUPAC Name

4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol

SMILES String

COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC

Physical Properties

No physical property values available.

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Whi-p131 (CAS 202475-60-3) is listed in the Advanced Chemicals portfolio, with molecular formula C16H15N3O3 and molecular weight 297. 31 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research building-block and synthetic chemistry workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Heterocyclic Building BlocksSynthetic ChemistryResearch intermediateCustom synthesis building blockResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens) — 2 assays; Epidermal growth factor receptor (Homo sapiens) — 2 assays; ALK tyrosine kinase receptor (Homo sapiens) — 2 assays; Vascular endothelial growth factor receptor 2 (Homo sapiens) — 2 assays; Tyrosine-protein kinase JAK1 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Proto-oncogene tyrosine-protein kinase receptor Ret

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 6.14

Experimental evidence source: ChEMBL

Epidermal growth factor receptor

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 5.93

Experimental evidence source: ChEMBL

ALK tyrosine kinase receptor

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 5.62

Experimental evidence source: ChEMBL

Vascular endothelial growth factor receptor 2

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents · best pChEMBL 5.55

Experimental evidence source: ChEMBL

Tyrosine-protein kinase JAK1

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 2 documents

Experimental evidence source: ChEMBL

Safety & Handling

Handling & Storage

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Disposal

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Fire Fighting

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Accidental Release

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Preliminary Safety Reference

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Names & Synonyms / External Identifiers

Chemical Name

Whi-p131

Names & Synonyms

Janex 1WHI P1314-((6,7-dimethoxyquinazolin-4-yl)amino)phenol4-(6,7-dimethoxyquinazolin-4-ylamino)phenolPhenol, 4-[(6,7-dimethoxy-4-quinazolinyl)amino]-
Show all synonyms
WHI-P 1314-[(6,7-Dimethoxy-4-quinazolinyl)amino]phenol4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazolinePHENOL, 4-((6,7-DIMETHOXY-4-QUINAZOLINYL)AMINO)-4-(4-hydroxyanilino)-6,7-dimethoxyquinazolineJANEX 1 [WHO-DD]Lopac0_001238WHI-P131(Janex 1)?s5903SDCCGSBI-0654296.P001W29334-(4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline4-[(4'-hydroxyphenyl)amino]-6,7-dimehtoxyquinazoline
External Identifiers
DSSTOX SUBSTANCE ID: DTXSID301226692CHEMBL ID: CHEMBL405130UNII: 1J8Q49TR3I
Literature & Patent References
DOI 10.1126/science.aan4368The target landscape of clinical kinase drugs.PMID 29191878The target landscape of clinical kinase drugs.DOI 10.1016/j.ejmech.2016.01.039The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity.PMID 26874741The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity.DOI 10.1016/j.bmc.2011.04.008Virtual screening and further development of novel ALK inhibitors.PMID 21515061Virtual screening and further development of novel ALK inhibitors.DOI 10.1039/C0MD00115ESelective inhibition of EGFR and VEGFR2 tyrosine kinases controlled by a boronic acid substituent on 4-anilinoquinazolinesDOI 10.1016/j.bmc.2007.10.066Anti-inflammatory activity profile of JANEX-1 in preclinical animal models.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

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What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

6,7-dimethoxy-N-phenylquinazolin-4-amineCAS 21561-09-1
N-(3,4-dimethoxyphenyl)-6,7-dimethoxyquinazolin-4-amineCAS 202475-65-8
4-(3-Hydroxyanilino)-6,7-DimethoxyquinazolineCAS 211555-08-7
Whi-P154CAS 211555-04-3
PD-153035CAS 153436-54-5

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 21561-09-16,7-dimethoxy-N-phenylquinazolin-4-amineCAS 202475-65-8N-(3,4-dimethoxyphenyl)-6,7-dimethoxyquinazolin-4-amineCAS 211555-08-74-(3-Hydroxyanilino)-6,7-DimethoxyquinazolineCAS 211555-04-3Whi-P154CAS 153436-54-5PD-153035CAS 1032900-25-6CeritinibCAS 120685-11-2MidostaurinCAS 1310726-60-3UpadacitinibCAS 443913-73-3VandetanibCAS 1002310-00-0Tert-butyl 1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamate

RFQ questions for CAS 202475-60-3

What are the key identifiers for Whi-p131 (CAS 202475-60-3)?

Whi-p131 is identified by CAS 202475-60-3, with molecular formula C16H15N3O3, molecular weight 297.31, InChIKey HOZUXBLMYUPGPZ-UHFFFAOYSA-N.

Does CAS 202475-60-3 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Proto-oncogene tyrosine-protein kinase receptor Ret, Epidermal growth factor receptor, ALK tyrosine kinase receptor, Vascular endothelial growth factor receptor 2, Tyrosine-protein kinase JAK1. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 202475-60-3?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Whi-p131?

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Is CAS 202475-60-3 available for quotation?

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