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Home/Compounds/CAS 202138-50-9
Formula C23H34N5O14PMW 635.5Research-use catalog entryCOA/SDS by request

Tenofovir Disoproxil Fumarate

CAS Number: 202138-50-9

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Loading RDKit molecule structure...
InChIKey: VCMJCVGFSROFHV-WZGZYPNHSA-NC23H34N5O14P | MW 635.5

Chemical Absolute Identifiers

CAS Number

202138-50-9

PubChem CID

6398764

Molecular Formula

C23H34N5O14P

Molecular Weight

635.5 g/mol

Exact Mass

635.183988

InChIKey

VCMJCVGFSROFHV-WZGZYPNHSA-N

IUPAC Name

[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphoryl]oxymethyl propan-2-yl carbonate;(E)-but-2-enedioic acid

SMILES String

CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc21)OCOC(=O)OC(C)C.O=C(O)/C=C/C(=O)O

Physical Properties

Water Solubility

13.4 mol/L

Properties are provided as catalog reference data and may be confirmed through supplier documentation when required.

Catalog Facts

Structural features

Tenofovir Disoproxil Fumarate (CAS 202138-50-9) is listed in the Pharmaceutical Intermediates portfolio, with molecular formula C23H34N5O14P and molecular weight 635. 50 g/mol.

Sourcing context

Catalog reference for RFQ preparation, supplier confirmation, and research chemical sourcing review.

Research use context

Intended for research-stage medicinal chemistry and intermediate synthesis workflows; structure-derived tags include nitrogen-containing heterocycle.

Documentation needs

COA/SDS status, availability, lead time, pack size, and shipment documentation can be confirmed during quotation.

Applications & Classification

Pharmaceutical Intermediate ResearchResearch intermediateCustom synthesis building blockPharmaceutical intermediate researchResearch chemical sourcingCustom synthesis and catalog availability reviewCOA, SDS, pricing, and fulfillment workflow
Biological target reference

ChEMBL reports experimental activity evidence for: Protein deacetylase HDAC6 (Homo sapiens) — 2 assays; Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens) — 2 assays. These records describe research assays and do not establish therapeutic efficacy or clinical use.

Protein deacetylase HDAC6

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Tyrosyl-DNA phosphodiesterase 1

Homo sapiens · SINGLE PROTEIN · 2 qualifying assays · 1 documents

Experimental evidence source: ChEMBL

Safety & Handling

Safety and handling reference content is available through documentation requests.

For supplier-issued SDS, request documentation before handling, storage, shipment, or procurement decisions.

Preliminary Safety Reference

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Safety Reference / SDS Request

Names & Synonyms / External Identifiers

Chemical Name

Tenofovir Disoproxil Fumarate

Names & Synonyms

VireadTenofovir DFPMPA prodrugVireaPMPA-PRODRUG
Show all synonyms
Tenofoviri disoproxili fumaras9-((R)-2-((bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine fumarate9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine, fumarateEVIPLERA COMPONENT TENOFOVIR DISOPROXIL FUMARATESTRIBILD COMPONENT TENOFOVIR DISOPROXIL FUMARATETRUVADA COMPONENT TENOFOVIR DISOPROXIL FUMARATEDELSTRIGO COMPONENT TENOFOVIR DISOPROXIL FUMARATETENOFOVIR DISOPROXIL FUMARATE COMPONENT DELSTRIGOViread Accesstenofovir disproxil fumarateTENOFOVIR DISOPROXIL FUMARATE Tablets2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, 1,9-bis(1-methylethyl) ester, 5-oxide, (2E)-2-butenedioate (1:1)Tenofovir Disoproxil Fumarate [USAN]TDFTenofovir Disoproxil (fumarate)
External Identifiers
EC NUMBER: 687-766-5DSSTOX SUBSTANCE ID: DTXSID5050426CHEMBL ID: CHEMBL1486CHEBI ID: CHEBI:63718UNII: OTT9J7900IKEGG ID: D01982NCI THESAURUS CODE: C47747PHARMGKB ID: PA166201941RXCUI: 322248WIKIDATA ID: Q27132754
Literature & Patent References
DOI 10.1016/j.ejmech.2024.117207Glycoconjugates of adefovir and tenofovir as asialoglycoprotein-mediated Anti-HBV prodrugs with enhanced liver targeting.PMID 39746236Glycoconjugates of adefovir and tenofovir as asialoglycoprotein-mediated Anti-HBV prodrugs with enhanced liver targeting.DOI 10.1016/j.bmcl.2024.129880Discovery of L15 as a novel Vif PROTAC degrader with antiviral activity against HIV-1.DOI 10.1016/j.ejmech.2023.116020Membrane-permeable tenofovir-di- and monophosphate analogues.DOI 10.1016/j.ejmech.2024.116948Sensitive quantification of fibroblast activation protein and high-throughput screening for inhibition by FDA-approved compounds.PMID 38086193Membrane-permeable tenofovir-di- and monophosphate analogues.PMID 38996941Discovery of L15 as a novel Vif PROTAC degrader with antiviral activity against HIV-1.PMID 39437576Sensitive quantification of fibroblast activation protein and high-throughput screening for inhibition by FDA-approved compounds.

Documentation & Compliance Facts

Compliance Facts

Shipment review: Required

Documentation available by request

Certificate of Analysis (COA): By request

Supplier Safety Data Sheet (SDS): By request

Purity and pack size confirmation: By request

Availability and lead time review: Confirmed by RFQ

Shipment documentation review: By request

For supplier-issued documentation by request, use the RFQ actions on this page.Review preliminary safety reference

What happens after RFQ

  1. 1We review the CAS identity, quantity, and documentation request.
  2. 2We check sourcing options, supplier availability, COA/SDS, purity, pack size, and lead time.
  3. 3We review destination and shipment documentation needs when applicable.
  4. 4We follow up with a quotation or clarification request.

Text Reference Cues

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Non-public related references

Diethyl P-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phosphonateCAS 180587-75-1
Tenofovir Alafenamide FumarateCAS 1392275-56-7
Phosphonic acid, P-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)-, hydrate (1:1)CAS 206184-49-8
Tenofovir AlafenamideCAS 379270-37-8
Phenyl hydrogen ((R)-1-(6-amino-9H-purin-9-YL)propan-2-yloxy)methylphosphonateCAS 379270-35-6

Non-public references are shown as text only and do not imply equivalence, availability, or shared use.

Catalog navigation

Related Catalog Entries

Other public CAS pages in this catalog. These links support navigation across additional intermediates and do not imply equivalence, availability, or shared use.

CAS 180587-75-1Diethyl P-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phosphonateCAS 1392275-56-7Tenofovir Alafenamide FumarateCAS 206184-49-8Phosphonic acid, P-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)-, hydrate (1:1)CAS 379270-37-8Tenofovir AlafenamideCAS 379270-35-6Phenyl hydrogen ((R)-1-(6-amino-9H-purin-9-YL)propan-2-yloxy)methylphosphonateCAS 35180-01-9Chloromethyl isopropyl carbonateCAS 147127-20-6TenofovirCAS 100643-71-8DesloratadineCAS 10083-24-6PiceatannolCAS 106516-24-9Sertindole

RFQ questions for CAS 202138-50-9

What are the key identifiers for Tenofovir Disoproxil Fumarate (CAS 202138-50-9)?

Tenofovir Disoproxil Fumarate is identified by CAS 202138-50-9, with molecular formula C23H34N5O14P, molecular weight 635.5, InChIKey VCMJCVGFSROFHV-WZGZYPNHSA-N.

Does CAS 202138-50-9 have reported biological target evidence?

ChEMBL contains qualifying experimental assay evidence associated with Protein deacetylase HDAC6, Tyrosyl-DNA phosphodiesterase 1. These records do not establish therapeutic efficacy or clinical use.

Can I request a COA for CAS 202138-50-9?

Yes. Submit an RFQ and specify COA requirements. Lot-specific COA depends on supplier confirmation.

Can I request supplier SDS for Tenofovir Disoproxil Fumarate?

Yes. Supplier SDS can be requested through the RFQ workflow before handling, storage, shipment, or procurement decisions.

Is CAS 202138-50-9 available for quotation?

Availability, pack size, lead time, and pricing are confirmed through RFQ.

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