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2-Chloro-6-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

CAS 1321518-08-4Formula C12H15BClF2NO2MW 289.51PubChem 129946540

This compound is a functionalized pyridine derivative containing a chlorodifluoromethyl group and a pinacol boronate ester. It is primarily intended for research and development applications, particularly as a versatile building block in organic synthesis.

Loading RDKit molecule structure...
InChIKey: VAZSDBVMWJRZDB-UHFFFAOYSA-NC12H15BClF2NO2 | MW 289.51

Chemical Identity

Molecular Formula

C12H15BClF2NO2

Molecular Weight

289.51 g/mol

Exact Mass

289.085243

PubChem CID

129946540

SMILES String

CC1(C)OB(c2cc(Cl)nc(C(F)F)c2)OC1(C)C

Names & Synonyms

VAZSDBVMWJRZDB-UHFFFAOYSA-N2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(difluoromethyl)pyridine
External Identifiers
SCHEMBL17667867CS-46998DB-302988

Catalog Overview

2-Chloro-6-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, with CAS 1321518-08-4, is a halogenated pyridine featuring a difluoromethyl group at the 6-position and a pinacol boronate ester at the 4-position, alongside a chlorine atom at the 2-position. This unique combination of functional groups makes it a valuable intermediate in synthetic chemistry. The pinacol boronate ester allows for various cross-coupling reactions, such as Suzuki-Miyaura coupling, while the chloro and difluoromethyl groups offer opportunities for further derivatization or serve as key structural elements in target molecules. It is...

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Read more catalog context

2-Chloro-6-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, with CAS 1321518-08-4, is a halogenated pyridine featuring a difluoromethyl group at the 6-position and a pinacol boronate ester at the 4-position, alongside a chlorine atom at the 2-position. This unique combination of functional groups makes it a valuable intermediate in synthetic chemistry. The pinacol boronate ester allows for various cross-coupling reactions, such as Suzuki-Miyaura coupling, while the chloro and difluoromethyl groups offer opportunities for further derivatization or serve as key structural elements in target molecules. It is suitable for use in academic and industrial research settings for the synthesis of novel compounds, including potential pharmaceutical intermediates and agrochemicals.

Physical Data

Estimated

Estimated / predicted physical property values for catalog reference.

Appearance

White to off-white solid

Physical State

Solid

Melting Point

95.0 °C

Boiling Point

280.0 °C

Density

1.45 g/cm³

Water Solubility

Slightly soluble

Flash Point

135.0 °C

Applications / Classifications

Research intermediateCustom synthesis building block

Biological Target Reference

No verified biological target assignment. This compound is listed primarily as a research or synthetic intermediate.

Preliminary Safety-Style Reference

Preliminary

Preliminary safety-style information for reference only. Not a supplier SDS.

Handling and Storage
  • Handle with appropriate personal protective equipment (PPE) including gloves, eye protection, and a lab coat. Use in a well-ventilated area or fume hood to avoid inhalation. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water. Store in a cool, dry place, away from incompatible materials. Consult the Safety Data Sheet (SDS) for comprehensive safety information before handling.

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